Yasumatsu, Ryuji1, Nakano, Takahumi1, Hashimoto, Kazuki1, Kogo, Ryunosuke1, Nakashima, Torahiko1 , Nakagawa, Takashi1
1 Department of Otorhinolaryngology, Head and Neck Surgery, Kyushu University, Japan
Background: Primary squamous cell carcinoma (SCC) of the thyroid is a rare disease accounting for < 1% of all thyroid malignancies. It usually presents with locally advanced disease and has an overall poor prognosis1). Diagnosis can be difficult because of the prevalence of squamous metaplasia in other primary thyroid cancers and direct intrathyroidal extension from locally aggressive SCCs. We undertook an analysis to investigate the characteristics and outcome of patients with SCC of the thyroid.
Patients and Methods: The management outcome of 10 patients who had SCC of the thyroid at Kyushu University Hospital or associated facilities was reviewed. There were 3 males and 7 females, ranging in age from 53 to 77 years. Extent of disease was staged as follows: stage IVA, 3 cases; stage IVB, 3 cases; stage IVC, 4 cases.
Results: Seven patients underwent surgical resection. Three other patients received palliative treatment. Radiotherapy and/or chemotherapy, such as paclitaxel or lenvatinib, following surgical treatment was applied for 6 cases. The one year actuarial survival rate of patients was 22.9%. There was no 2-year survivor of all patients.
Discussion and Conclusion: Prognosis is generally very poor because of the rapid growth and metastasis of the tumor. There was a little chance of cure after treatment of SCC of the thyroid. Due to the rarity of this disease, there are no standardized guidelines for the treatment of primary SCC of the thyroid. The diagnosis and treatment strategy for this rare tumor will be discussed.
- Syed MI, et al. Squamous cell carcinoma of the thyroid gland: primary or secondary disease? J Laryngol Otol 2011;125:3–9.