EP141 – Clinical significance of PET CT in recurrent papillary thyroid cancer


    Shin, Sung-Chan1; Kang, Ji-Heon 1; Yoon, Byung-Woo1; Jung, Da-Woon1; Kim, In-Joo2; Kim, Bo Hyun2; Lee, Jin-Choon3; Lee, Byung-Joo1
    Department of Otorhinolaryngology-Head and Neck Surgery, Biomedical Research Institute, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Republic of Korea
    Division of Endocrinology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
    Department of Otorhinolaryngology-Head and Neck Surgery, Biomedical Research Institute, Pusan National University School of Medicine, Yangsan Pusan National University Hospital, Yangsan, Gyeongsangnam-do, Republic of Korea


    Introduction: 18F-FDG PET/CT has been widely accepted as an effective method for detecting PTC recurrence. This study was performed to evaluate the diagnostic value of PET/CT for PTC recurrence evaluation in patients already diagnosed as loco-regional recurrent disease and the role for predicting the prognosis.

    Materials and Methods: Sixty-six recurrent patients were enrolled. 18F-FDG PET/CT was performed within the 6 month before surgery. The 18F-FDG PET/CT findings were compared with the histopathological examination results.

    Results: The sensitivity, specificity, and diagnostic accuracy of whole neck level (II-VI) were 38.5%, 86.5%, and 57.4%, respectively. Corresponding values for central neck compartment were 54.8%, 66.7%, and 57.5% and values for lateral neck compartment were 59.7%, 75.0%, and 61.4%, respectively. Diagnostic values for lateral compartment tended to be higher than values for cental compartment. The diagnostic accuracy of 18F-FDG PET/CT for detecting recurrence in whole patients irrespective of Tg levels was 42.4-64.3% by levels and compartment. Patients with a Tg level ? 2 ng/ml show 26.3-75.0% of corresponding values. In addition, patients with a Tg < 2 ng/ml show 47.4-75.0% of corresponding values. In a comparison of the high FDG avidity group (SUVmax > 10) and the others, median loco-regional disease free survival time were 81.8 and 33.3.(p <.001)

    Conclusion: 18F-FDG PET/CT demonstrate the comparable diagnostic value for detecting recurrence, irrelevant to WBS results and serum Tg and TgAb levels. Therefore, 18F-FDG PET/CT may also helpful for the evaluation loco-regional / distant recurrence.



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