Osorio, Marcela1; Roche, Ansley2; Urken, Mark L.1,2
1 Thyroid, Head and Neck Cancer (THANC) Foundation, New York, NY, USA
2 Department of Otolaryngology – Head and Neck Surgery, Mount Sinai Downtown, New York, NY, USA
Background/Purpose: Carcinoid tumors are rare, low-grade neuroendocrine tumors commonly occuring in the gastrointestinal tract. We present a case series and review the literature on synchronous Papillary thyroid cancer (PTC) and carcinoid tumors, a finding that has only been described once before in the literature.
Methods: Two female patients in their 7th decade underwent evaluation for a chronic cough. Fluorine-18 flurodeoxyglucose (FDG) positron-emission tomography (PET) revealed hypermetabolic pulmonary, thyroid, and cervical lymph node lesions in both patients. In addition, patient A had a high retropharyngeal lymph node that was hypermetabolic and biopsy positive for papillary thyroid carcinoma (PTC). We performed an analysis of the Surveillance, Epidemiology, and End Results (SEER) database to determine the rate of synchronous Well-differentiated thyroid carcinoma (WDTC) and carcinoid tumor.
Results: Fine-needle aspiration (FNA) of a cervical lymph node in each patient showed metastatic PTC. FNA of both patients’ pulmonary nodule demonstrated carcinoid tumor. Both patients underwent total thyroidectomy and lateral neck dissection. The patient with a retropharyngeal lymph node underwent retropharyngeal lymph node resection. According to the SEER 9 registry, approximately 1 in 1 million people will have both WDTC and carcinoid tumor.
Discussion & Conclusions: We present a case series and literature review on synchronous PTC and carcinoid tumors. Approximately 1 in 1 million people will have both WDTC and carcinoid tumor; however, given the rare nature of this occurrence, there are not enough reported cases to determine whether this represents a higher rate of occurrence compared to the rate of occurrence of each tumor type individually.