Xiang, Mingliang1; Ye, Bin1; Lu, Jingrong1
1 Department of Otolaryngology & Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine
Background: The prevalence of differentiated thyroid cancer (DTC) is increasing in children. However, the clinical features of children DTC recurrence and no recurrence cases in different age groups, especially those less than 14 years old, are not well studied.
Methods: We retrospectively investigated 73 children diagnosed with DTC in our hospital between January 1998 and July 2014. Data were reviewed for different age groups based on the age at initial diagnosis: 5-9 years, 10-14 years, and 15-19 years.
Results: The mean age of the recurrence group was 10.6±4.1, which was lower than that of the non-recurrence group (P=0.004). The main symptom of the recurrence group at initial diagnosis was local invasion, which was different from that of the non-recurrence group (P?0.001). Significant differences were not observed between the recurrence and non-recurrence groups for TNM stage or risk level. According to our age classification, ATA pediatric risk level was negatively correlated with age (P=0.024). The recurrence rate in each age group exhibited a decreasing trend as the age of the DTC children increased (P=0.011).
Conclusion: Altogether, our findings suggest that younger DTC children present a higher risk of tumor recurrence. A high risk of recurrence and a high proportion of local invasion were observed in the younger age group, which suggests that a younger age is an important risk factor for DTC recurrence in children.