OP109 – Clinical Analysis of Carcinoma Showing Thymus-like Differentiation of the Thyroid

     

    Wang, Yunjun1; Sun, Tuanqi1; Xiang, Jun1; Wang, Zhuoying1;  Li, Duanshu1;  Wu, Yi1
    1 Department of Head and Neck Surgery, Fudan University Shanghai Cancer Centre

    Objective: To analyze the clinicopathologic features, diagnosis, treatment and prognosis of ?carcinoma showing thymus-like differentiation of the thyroid? CASTLE?in order to improve the ability of managing it.

    Method:  Patients of surgically resected specimens of CASTLE were collected in Head & Neck Surgery Department, Fudan University Shanghai Cancer Centre from 2007-09-01to 2015-09-01. Characteristics of preoperative imagine examination (e.g. ultrasound and CT scan), cytological examination, treatment, histologic and immunohistochemical results and prognosis were analyzed retrospectively.

    Results: 16 patients were included in this study, and all accepted surgery. Postoperative radiotherapy was practiced in 13 patients. The immunohistochemical results showed that CD5, CD117 were almost positive in all patients while Tg, TTF-1, Calcitonin were negative. 4 patients were lost to follow-up. The rest 12 patients were alive without tumor recurrence and metastasis (median follow-up period 43.3±28.6 months).

    Conclusion: CASTLE is a low malignant tumor with a slow progression and good prognosis. CD5 and CD117 play an important role in differential diagnosis. Radical surgery is the first choice of treating CASTLE while postoperative radiotherapy might reduce local recurrence.

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