Duque, Carlos S.1, Nikiforov, Yuri2, Vélez, Alejandro3, Nikiforova, Marina2, Cuartas, Jorge4, Dueñas, Juan Pablo5, Jaimes, Fabián1, Botero, José Fernando6
1 Hospital Pablo Tobon Uribe, Clinica Las Americas, Medellín, Colombia
2 Division of Molecular & Genomic Pathology, University of Pittsburgh Medical School, Pittsburgh, USA
3 Hospital Pablo Tobon Uribe, Dinamica, Medellin, Colombia
4 Clinica Orlant, Medellín, Colombia
5 Hospital Pablo Tobon Uribe, Instituto de Cancerologia, Clinica Las Américas, Medellín, Colombia
6 CLID Medellín, Colombia
Background: Exposure to radiation sources has been found to be a triggering factor to develop thyroid cancer especially in the younger population. Exposure to radiation might occur accidentally or chronically during some ones daily activities Within the health care system there are some professionals that might be chronically exposed and at risk to develop malignancies such as a thyroid cancer. The present study reviewed the pathologic slides of nine doctors (MD and DDS) exposed to radiation sources during their professional life who developed papillary cancer.
Purpose: To review the past occupational history of each patient in relation to their exposure to radiation sources and to perform specific DNA, RNA and molecular studies in the pathology slides of the nine patients in order to see if their past and present exposure to radiation explained their thyroid cancer
Methods: Targeted next generation sequencing analysis for driver point mutations associated with sporadic carcinogenesis and for gene fusions associated with radiation thyroid carcinogenesis was performed using ThyroSeq v2 mutation panel.
Results: After performing all available molecular, DNA and RNA studies on 8 of the patients slides it was concluded that none of their thyroid cancer was related to radiation as n clear findings in this regard were seen with the tumor cells
Discussion: Even though a “short” series, no relationship was observed between the exposure to radiation and the development of papillary thyroid cancer in these patients. Their tumor cell did not show any evidence of changes due to radiation