Dionigi, Gianlorenzo1, Lavazza, Matteo1, Pappalardo, Vincenzo1, Inversini, Davide1, Xiaoli, Liu2, Wu, Che-Wei3, Anuwong, Angkoon4, Kim, Hoon Yub5, Liu, Renbin6, Gregory W. Randolph7
1 1stDivision of General Surgery, Research Center for Endocrine Surgery, Department of Surgical Sciences and Human Morphology, University of Insubria (Varese-Como), via Guicciardini 9, 21100 Varese, Italy
2 Jilin Provincial Key Laboratory of Surgical Translational Medicine, Japan Union Hospital of Jilin University, Division of Thyroid Surgery, Changchun city, Jilin Province, China
3 Department of Otolaryngology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City – Taiwan;
4 Department of Surgery, Police General Hospital, Faculty of Medicine, Siam University, Pathumwan, Bangkok, Thailand
5 KUMC Thyroid Center Korea University, Anam Hospital Seoul-Korea;
6 The Third Affilated Hospital of Sun Yat-sen University, 600 Tianhe Rd. Guangzhou 510630, China
7 Division of Thyroid and Parathyroid Surgery, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, Massachusetts, U.S.A.
Background: purpose of this prospective study was to evaluate incidental thyroid cancer diagnosed by ultrasonography (US) in a population who underwent carotid echography.
Subjects & Methods: Between January 2013 and March 2016, we examined thyroid glands during routine diagnostic, follow-up carotid US. A total of 3,533 subjects underwent carotid screening ultrasound (n = 2,662) or US for diagnosis or follow-up (n = 871). When a thyroid lesion was suspicious for malignancy, fine-needle aspiration was performed. We compared the cases of pathologically proven thyroid cancer in two groups: first group, including patients with carotid disease found, and a second group, including patients with negative findings.
Results: Among the 3,533 cases, 44 (1.24%) were diagnosed as thyroid cancer; all were papillary carcinomas. Pathologically proven thyroid cancers were identified in 14 (1.6%) of the 871 patients with carotid disease and in 30 (1.12%) of the 2,662 non-vascular disease patients (p>0.05). The diameters of the 44 thyroid nodules were 0.7-3.7 cm; the mean diameters in the first and second groups were 12.9 and 11.6 mm, respectively (p>0.05).
Discussion & Conclusion: The incidence of thyroid cancer was similar in both group. The results of routine concurrent US carotid and thyroid examinations were helpful in detecting thyroid tumors in both patient groups.