EP109 – Clinical and Histopathological Predictors of Recurrence in Patients With Differentiated Thyroid Carcinoma In Colombia: A Multicentric Study

      Dueñas, J.P.4; Wandurraga, EA1; Marín Carrillo, L.F.2; Torres, J.L.3; Aristizábal, C.3; Aristizábal, N.3; Sylva, D.I.3; Ospina, D.C.1;  Natera, A.K.2; Gómez, C.M.2; Rondón Sepúlveda, M.A.5 1 Faculty of Medicine, Autonomous University of Bucaramanga UNAB. Division of Endocrinology, FOSCAL International Clinic. Bucaramanga, Colombia 2 Faculty of Medicine, Pontifical Xaverian University. Division of Endocrinology, Hospital San Ignacio. Bogotá, Colombia 3 Faculty of Medicine, Pontifical Bolivarian University. Division of Endocrinology, Clinic of the Americas. Medellin, Colombia 4 Division of Endocrine Surgery, Clinic of the Americas. Medellin, Colombia 5 Faculty of Medicine, Pontifical Xaverian University. Division of Epidemiology and Statistics, Hospital San Ignacio. Bogotá, Colombia   Background/Purpose: Differentiated thyroid cancer, despite not having a high mortality rate, entails an important morbidity burden, given mainly by recurrence. It was our objective to determine the associated factors with relapse in patients with thyroid cancer in 3 hospitals in Colombia. Methods: A retrospective descriptive study was conducted. Demographic, clinical and histopathological characteristics were collected from medical records of patients attended during 3 years. Recurrence was defined as the evidence of locoregional structural disease confirmed by pathology or distant metastatic involvement through suggestive anatomic or functional images, beyond 12 months with no evidence of disease after the initial therapy. Results: 481 patients were included. 14.3% were males and 59.3% were over 45 years. 97% of cases had papillary carcinoma. The mean time of follow-up was 5.1±4.9 years. Tumor relapse was documented in 16.8% of subjects with a median time of 3 years since initial therapy. Association between recurrence and tumor size, extrathyroid extension, metastatic/resected lymph node ratio (central and total) and extranodal extension was found in the univariate analysis. The total amount of metastatic lymph nodes ?2 (HR 4.10, CI95%1.07-4.85) and a value of preablative stimulated thyroglobulin ?7.29 ng/ml (HR 2.28, CI 95%1.07-4.85, p=0.031), were the only two significant features related to recurrence in the multivariate analysis. Conclusions: We suggest that patients with 2 or more metastatic total lymph nodes might be classified at least as intermediate recurrence risk. Additionally, we found that a cutoff value of preablative stimulated thyroglobulin less than 7.29 ng/ml was associated with a low recurrence risk.   References:
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