EP2 – Right ventricular outflow obstruction induced by tumor embolus of anaplastic thyroid carcinoma

      Maeda, Hiroyuki1, Terukina, Reina1, Noha, Masashi1, Kinjo, Hidetoshi1, Uezato, Jin1, Agena, Shinya1, Matayoshi, Sen1, Suzuki, Mikio1. 1 Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan   Background: Anaplastic thyroid carcinoma (ATC) is an aggressive malignancy with median survival of six months. In general, distant metastases occur at lung and bone early in the course of disease in most other cases. However, clinically evident cardiac metastases from primary malignant neoplasms are uncommon. On the other hand, it is known that ATC is one of the few malignant tumors to metastasize to the heart. We present a case of ATC with metastatic involvement of the heart. The patient is 74 years old woman. Pulmonary artery trunk was excised with tumor embolus at first. After that, primary ATC was found and total thyroidectomy and bilateral neck dissection was performed. However, distant metastasis to pelvis was found and new embolus inside right ventricle or pulmonary artery trunk without a break. Results: Although we used tyrosine kinase inhibitor (TKI) and try to prolong her expectation of life, she died from cardiac problem finally. Conclusion: ATC is aggressive carcinoma with a miserable prognosis. It should be borne in mind that possibility of cardiac metastasis and a cause of cardiac death.


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