EP43 – Incidence of thyroid cancer: can we assume its increase only based on over diagnosis?

      Figari, Marcelo1; Russo Picasso, Maria2; Vicens, Jimena3; Giménez Giuliani, Carina1; Jaén, Ana4; Cabezón, Carmen2; Gómez Saldaño, Ana3, Figar, Silvana3 1  Head and Neck Surgery Section, Department of General Surgery, Hospital Italiano, Buenos Aires, Argentina 2 Endocrinology and Metabolism Service, Hospital Italiano, Buenos Aires, Argentina 3 Epidemiology and Public Health Department, Internal Medicine Service, Hospital Italiano, Buenos Aires, Argentina 4 Anatomic Pathology Service, Hospital Italiano, Buenos Aires, Argentina   Baclground/ Purpose: This study aims to compare the epidemiological profile of thyroid cancer (TC) along two time frames in a private University Hospital in Buenos Aires, oriented to understand the phenomenon of increased incidence reported in the last decades. Methods: Retrospective cohort study, identifying incident cases of TC from the pathological report of patients in the Hospital health system. Clinical records were reviewed recording patients and tumor characteristics. The results were analyzed in periods: 2003-2007 and 2008-2012. A descriptive and analytical analysis was performed comparing periods (significance level 0.05). Incidence rates adjusted for each 100,000 person-years (with 95% CIs) and relative risk of incidence rates of incidental and non-incidental CT were estimated. Results: 189 patients with TC treated in 2003-2012 were reviewed. The mean age (57 years, ±15) and the percentage of women (83.6%) were similar in both periods. The tumor mean size was significantly lower in the most recent period (10 vs 14 mm, p <0.03). Tumors greater than 41 mm increased in the most recent period, but without statistical significance (2.1% vs 7%). The female / male ratio decreased between analyzed periods: 8 (3-21) vs 4 (3-7). The relative risk between incidentally and non-incidentally detected tumors decreased between both periods: 6.1 (1.8-20.0) vs 1.8 (1.1-2.8). Conclusion: Our findings partially support the increased incidence due to the early diagnosis of small tumors, but do not explain the changes in the increase of larger tumors and decrease in the ratio of woman to male, adding elements to the debate of environmental causes.


Leave a Reply