Examination of Distant Metastasis Case in Differentiated Thyroid Cancer

  • Distant metastasis is a prognostic factor in thyroid differentiated cancer. There were 41 cases of differentiated cancer among 60 cases of thyroid cancer treated in our department from 2006 to 2018. The 5-year disease-specific survival rate (DSS) of 41 differentiated cancer was 92.5%. There were 12 cases with distant metastasis, the 5 year DSS was 54.5% The 5 year DSS of 29 cases without distant metastasis was 81.8%, and a significant difference was observed. Seven patients (17%) had distant metastasis at the first visit in the distant metastasis cases, and five patients (12%) who had distant metastasis during the follow – up. Three cases (25%) of the distant metastasis cases were dead of disease. Both cases were distant metastasis from the first visit. The other 9 cases were no evidence of disease. In all 4 patients with distant metastasis rapidly increased, the diameter of the primary tumor was more than 5 cm in advanced cancer. In 3 of 4 cases, enlarged resection such as resection of trachea or total laryngectomy were performed at the initial treatment. Three patients who underwent operation had local recurrence and brain metastasis after treatment, but salvage treatment prolonged survival time.

    Discussion Distant metastasis is a prognostic factor of thyroid differentiated cancer, and tends to increase rapidly in locally advanced cases with distant metastasis from the initial diagnosis. Control of local recurrence or distant metastasis by salvage treatment was considered to be important.


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