Long-term Prognosis of Papillary Thyroid Carcinoma

  • Background:
    Since papillary thyroid carcinoma (PTC) is a slow-growing tumor, there are cases where recurrence and/or metastasis occurs after more than 10 years have passed since the treatment. Although the patients with PTC generally have a good prognosis, it is important to consider the long-term outcome.

    Methods:
    A retrospective study was conducted on 452 patients with PTC who underwent the initial operation from 1977 to 1996 at our institution. The ratio of males and females was 1:8, the average age at the initial surgery was 52 years, and the mean observation period was 20 years.

    Results:
    The overall survival rate at 10, 20 and 30 years was 89%, 83%, 67% respectively. The disease-specific survival rate at 10, 20 and 30 years was 97%, 95%, 92% respectively. The death of PTC was 23 cases and distant metastasis was the most prevalent pattern with 14 cases. N1b and over 55 years old influenced the prognosis in the multivariate analysis. The disease-free survival rate at 10, 20 and 30 years was 88%, 81%, and 79% respectively. In 19 cases the first recurrence occurred after 10 years or more after surgery.

    Discussion & Conclusion:
    This report is a very long-term treatment result at a single institution.
    N1b and over 55 years old are significantly influenced the prognosis and it is important to consider the long-term follow-up.

 

Leave a Reply