OP76 – Health-related Quality of Life in Asian Thyroid Cancer Survivors: Development of a simple screening tool

      Chan, Wing-lok1, Choi, Horace Cheuk-wai2, Lee, Victor Ho-fun2, Wan, Koon-yat1, Chan, Michelle Fong-ting1, Wong, Kai-pun3, Lang, Brian3, Yuen, Kwok-keung1, Leung, To-wai1 1 Department of Clinical Oncology, Queen Mary Hospital, Hong Kong, Hong Kong 2 Department of Clinical Oncology, Li Kai Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong 3 Department of Surgery, Li Kai Shing Faculty of Medicine, The University of Hong Kong, Hong Kong   Background: Health-related quality of life (HRQoL) is important in thyroid cancer survivors, but data is lacking among Asian. Objectives: This cross-sectional study aimed to identify any disease-related/ treatment-related factors that affect HRQoL in Asian thyroid cancer survivors and to develop a simple tool to identify patients who need additional support. Methods: All adult differentiated thyroid cancer patients with stable disease >=1 year received a survey on HRQoL using EORTC QLQ-C30 and THYCA-QoL (total: 54 questions). Determinants for HRQoL were selected using multiple linear regressions with backward elimination. For QLQ-C30 and THYCA-QoL domains which could discriminate patients with or without unmet needs, the potential cut-off scores were calculated using receiver operating characteristic (ROC) curve. Results: A total of 549 patients completed both questionnaires (response rate: 86.9%; female: 79.6%; median survivorship: 7.4 years [1.0-48.2]). Patients with age>=45, TSH>1.85mIU/L, previous radiotherapy and psychiatric illness reported significantly worse QLQ-C30_summary-score (coefficients 2.7-11.3, p<=0.016) and THYCA-QoL_total-score (coefficients 2.7-9.1, p<=0.029). Psychiatric illness (n=34/549, 6.4%) also showed significant effect in most of the symptom scales. Global Health Status (GHS) in QLQ-C30 was highly predictive for overall HRQoL (QLQ-C30_summary-score and THYCA-QoL_ total-score). Cut-off of 10/14 in GHS could distinguish the bottom 18.9 and 25.1% in our population, respectively (area under ROC curve [AUC]>=0.79, sensitivity (SN)>=0.81, specificity (SP)>=0.61). Moreover, cut-off of 7/16 in THYCA-QoL_psychological-scale (AUC=0.75, SN=0.884, SP=0.612) could screen those at risk of psychiatric illness. Conclusions: Factors decreasing HRQoL included age>=45, TSH>1.85, previous radiotherapy and presence of psychiatric illness. Using GHS and THYCA-QoL_psychological-scale as a six-item tool can easily identify those with lower HRQoL or risk of psychiatric illness.   References:
    1. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, . The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993;85:365–76.
    2. EORTC QLQ-C30 manual.  Available at https://www.eortc.be/qol/files/SCManualQLQ-C30.pdf
    3. Husson OHaak HRMols FNieuwenhuijzen GANieuwlaat WAReemst PHHuysmans DAToorians AWvan de Poll-Franse LV. Development of a disease-specific health-related quality of life questionnaire (THYCA-QoL) for thyroid cancer survivors. Acta Oncol. 2013 Feb;52(2):447-54. doi: 10.3109/0284186X.2012.718445. Epub 2012 Sep 27.


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