Primary mucoepidermoid carcinoma of the thyroid: First report of a rare case with bone metastasis and review of the literature

  • Purpose: The aim of the study was to report the first case of mucoepidermoid carcinoma (MEC) of the thyroid with bone metastasis when admitted to hospital, review the literature, and emphasis the treatment in this potentially aggressive malignancy.

    Methods: A 55-year-old man had initially presented to our hospital with a painful lumbar spine and left pelvis bone . His PET/CT scan revealed a mass on the left thyroid gland, multiple metastasis at L4, L5, S1 spine bones and the left pelvis bone. She subsequently underwent total thyroidectomy. Surgical pathology was significant for MEC.

    Results: The patient underwent completion total thyroidectomy and neck dissection. Operative findings included 1 lymph nodes positive for metastasis. Palliative postoperative radiotherapy in bone metastases management was administered with 30 Gy in 10 fractions. The patient died 7 months after the last treatment.

    Conclusion: Mucoepidermoid carcinoma is a rare malignancy of the thyroid with less than 8 cases with poor prognosis reported to date. Although MEC of the thyroid has frequently been reported as low grade, but rarely has aggressive behavior. Here, we present the first case with bone metastasis as the first symptom of the MEC and review of the published literature.


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